Isopropylamine/NONOate (IPA/NO) Elicits NO-independent Antihypertrophic Actions via cGMP Signalling
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چکیده
منابع مشابه
NO/cGMP signalling in platelets
Background NO/cGMP-signalling is important for the inhibition of platelet aggregation. The cGMP dependent protein kinase I plays thereby the key role in the signal cascade of NO/ cGMP. It is already known that the interaction of the cGKI substrate IRAG with the IP3RI is essential for the NO/ cGMP dependent inhibition of platelet aggregation. To specify the relevance of IRAG signalling for plate...
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Proteinase-activated receptors (PARs) are a novel class of G protein-coupled receptors that respond to signals through endogenous proteinases. PAR activation involves enzymatic cleavage of the extracellular NH(2)-terminal domain and unmasking of a new NH(2) terminus, which serves as an anchored ligand to activate the receptor. At least four PAR subtypes have been identified. In the present stud...
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Most of the effects of the signalling molecule nitric oxide (NO) are mediated by the stimulation of the NO-sensitive GC (guanylate cyclase) and the subsequent increase in cGMP formation. The enzyme contains a prosthetic haem group, which mediates NO stimulation. In addition to the physiological activator NO, NO-sensitizers like the substance YC-1 sensitize the enzyme towards NO and may therefor...
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Background Over the last decade, we have shown that cGMP, derived from bradykinin, nitric oxide (NO•, both from endogenous and exogenous sources) or natriuretic peptides, is a potent inhibitor of cardiac hypertrophy, across isolated cardiomyocytes and intact hearts both ex vivo and in vivo. However, NO• bioavailability is reduced due to scavenging by ROS; furthermore, oxidation of sGC may resul...
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The role of nitric oxide (NO) in the human pancreas and in pancreatitis still remains controversial. Furthermore, conflicting conclusions have been reached by different laboratories about the localization of the NO-generating enzyme (NO synthase, NOS) in the pancreas. Here, we investigated the co-expression of NOS with enzymes involved in regulation of NO signalling in the normal human pancreas...
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ژورنال
عنوان ژورنال: Heart, Lung and Circulation
سال: 2012
ISSN: 1443-9506
DOI: 10.1016/j.hlc.2012.05.155